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Write for me science capstone project ideas cheap latin word for oneness need dissertation conclusion on censorship plz ´╗┐hi I'm Tom Phipps I was a teacher and got diagnosed with Parkinson's when I was 50 years of age my name is Alan Wayne and I'm a consultant urologist with an interest in Parkinson's disease at French hospital at Bristol when the opportunity came to take part in the research trial I just jumped at the chance this trial is based on some prior work that was done here at French eh and elsewhere where it seemed there was real potential that if you took patients who've lost dopamine brain cells and you gave a growth factor direct into their brain the growth factors called G TNF that you can cause brain cells in some way to restore themselves so you could actually reverse their Parkinson's we're now trying to do this in a more advanced way and are looking to recruit 36 people to try and answer this question is G D and F capable of reversing Parkinson's or not we're looking for patients with Parkinsons who are aged between 35 and 75 that they've had movement symptoms of Parkinson's be it tremor or stiffness slowness of movement for five or more years that their Parkinson's is to a degree controlled but not fully controlled so in other words patients who have what are called motor complications so there are parts of the day when their symptoms are really well controlled by medication at other times in their day where they become slower or stiff the medications not working so well my name is Lucy Mooney and I'm the lead movement disorder nurse specialist and the senior research nurse here at French hospital and I'm the trial coordinator for the GTF trial so I really am the first point of contact for patients as they make their way through the trial when we receive an expression of interest form here at French je the first thing that we will do is we'll contact you by phone to undertake some preliminary screening to see if there's a possibility that you may be suitable based on the information that you've provided I approached Lucy Mooney of the research nurse and I put my name forward my wife and I went for an interview and I was then assessed for my suitability for the for the project if they seem suitable we would then have them down to French I Hospital in Bristol for visits to go through in detail with them what would happen in the trial and they so they understand the risks because there are risks attached to the surgery and receiving a therapy surgery itself involves having a system put in place where you have four tubes two on either side which go down through the scalp it's all under the skin when it's finished so you can't see this part and those tubes go down deep within the brain and end in a part of the brain that's particularly affected by Parkinson's and then the G D and F or growth factor is given down those tubes the surgery is so good because they don't Scout at they don't take you to shave your head they just take a section across the scalp peel it back and Angela through the scalp if we don't hope the skull at all and then they feed the pipe through the back and into the port which is set into the bone on the side of the scale which allows us on a monthly basis to connect a pump system outside the rail allows us to give the drug or placebo through the port and deep down into the brain so all that's visible is a little port behind it here but the surgery to put that in takes a part of a day and then the patient normally would go home a couple of days later here's the port it's quite discrete and it's just behind the ear and it was developed by a very good company of mechanical engineers I've got excellent faith in and they come to the the surgery and check it through as it's being delivered and and make sure it works properly and they're really good bunch of guys you've got a port in in this system in you can go swimming or flying an aeroplane they essentially live a normal life and every month they come and have an infusion and the infusions are done here in this room but we also obviously want to assess how they're doing and always seeing improvements and the way we do that is that we do assessments of their clinical status every two months or eight weeks and that's done by taking them off medication so that can be a bit unpleasant for patients you can't do a trial without perceiver being a scientist eyes that it's not it's not a proper trial if you don't have a placebo but you're not doing it you know you should have a blind trial so that you you know the only change that can happen is as a result of the drug it doesn't put me off because I know that when my time of the nine months finishes which is literally in the next couple of weeks I will go on to the drug anyway so at the end of nine months of having infusions of either the gene F or placebo then all of the participants will roll on into what's called an extension phase which lasts a further nine months during that nine month period all of the participants will receive G D and F so for the first nine months you've got a 50/50 chance of having the active treatment or placebo for the second nine months all patients will have the active G TNF treatment so we do appreciate that this is a very intensive trial and that people may be put off by the time commitment but also by the the level of involvement and the surgery itself and so forth and it may be very daunting for them initially it's quite intense we've got two weeks to recover from the operation you can't go to work I didn't work anyway but it you can't do much the assessments take two days out because we've got day with that as you'd reduce your medication one of the things I had to do was miss the first week of my holiday this year because I had an infusion on the first week that the family were going abroad the dressing around you around the head was was quite uncomfortable to wear but it was a good talking point people would ask what if what you've done I said I have had brain surgery what well you've done that for I said because I'm part of a trial why I said because I want to be part of the trial and and you know this it's like a sort of badge of honor really it sounds a bit crazy but there's a sort of altruistic thing that I wanted to do it for other people but also to be to be recognized for having done something for somebody else is also quite important I think the project is absolutely brilliant I think the the team are fantastic everybody I've spoken to in the team have been really really good they're really friendly and as a try list you have part of a team the consultant and the the research nurse and the and the the senior consultant surgeon and it's almost first-name terms because you're all doing the same thing you're working towards the same end which is the result of a major trial so this trial isn't for everybody but I do feel that there will be many people out there with Parkinson's who will see this as an opportunity to become involved in research and to potentially become involved in finding a treatment that could benefit them but also potentially other generations to come you should read all the information that's on the Parkinson's UK website regarding the try and including the full patient information leaflet and I would suggest it's a good idea maybe to print that off and share that with your family and friends if you want further information then you can also discuss it with your specialist Parkinson's nurse or your neurologist or your GP and if you have unanswered questions then you would be free to fight phone us here at French gym we would be happy to answer any questions that you have if you're keen and taking part in the trial you should then complete the expression of interest form that's on the website which will then be sent to us our team here at Frenchie and then we'll make contact with you you do my engineering capstone conference Globalization and International Affairs 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