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Psychology capstone project examples cheap good research topics on gender shahtaj sugar mills annual report 2018 telekom good evening thank you for having me here imagine a person have a heart attack the blood flow stops wouldn't be wonderful to have a medicine that can be delivered outside to save the person's life imagine a football player on our team injured on the field with a concussion what can we do our comrade soldier is facing a life threatening injury on the battlefield you need of an urgent treatment to stop the bleeding and trauma an elderly person is suffering on a daily basis of Alzheimer disease a chronic injury to the brain how can we help what do all these things have in common they all have consists of injury to our body or to the elemental cells are composed of different organs you may be wondering why I'm showing a picture of a salamander this salamander is such a unique animal species that has this amazing regenerative capacity survival capacity it can repair and regrow a broken limb very quickly and efficiently how human body cannot do it now imagine what if there is a pixie dust that you can sprinkle on the wound or deliver to the body at a time of urgent need to cure or leave it the traumatic injury just like a settlement so a few years ago my students and co-workers identified a gene named mg 53 that function as a molecular pendant to repair tissue injury shown here are three cells that has been treated with mg 53 the pixie dust which is labeled with bright color green on the left you see a cell that being injured soup walking by a needle you can see that empty 53 can cease injury and quickly moved to the injury side to form a repair patch just like fixing a flat tire in the middle you see a cell is being severed by a knife normally the cell will die but because of the presence of mg 53 protein it can quickly seal the border to enable the cell to survive in the right you see a cell that's being poked many times on the brink of time miraculously you see that the protein come to the rest rescue to reverse dying process seeing I am here you cannot die so we now know that mtv3 is a protein that present in our body that safely circulates in the blood stream with one important physiological function that is a protect our our body against injury our task is to translate these basic findings into treatment of human diseases to do so we have to first manufacture the protein in large and good-quality quantities for human applications now that we have done so so I have here a vial that contains a localized protein so our task next is to put the deliver the protein to the injured site one way to do that is to through the formulation of a topical cream but we want to think even bigger to find another way to deliver this magical protein so over the past few years we have collaborated with researchers and clinicians scientists and found that the protein can function profile actively and therapeutically to protect against injury to the heart to the brain to the skin and to the lung so here is a picture of a heart attack that's evidenced by the pale large peel region in the section of an injured heart so on the right if you have a another heart that also suffered a heart attack but has been treated with mg 53 protein as you can see clearly this is a much healthier heart that the pill regime has a disappeared and heart cells are no longer dial so here are the mice that has a neuromuscular disease that is equivalent to the human ARS disease they cannot move on the left because of the injury to their muscle and bring on the right you have you have the little maid mice that have the same genetic disease but have been treated with the protein look at how active and mobile they are these findings support the value for the usage of mg 53 protein to treat chronic brain injuries in such as Alzheimer's or ARS and if it is protein in the form of a topical cream which I have example here can facilitate healing of injury to the skin here is a picture of second-degree coffee burn before and after treatment with mg reduce reproaching here is a picture of a chronic injury in elderly person with topical application of the protein you can see the wound heals but more importantly you see there's no scarring medication of scarring is such a new one very unique picture of the protein such findings shall have very important implication to the wound care and personal care market where there is a great need for scar and wrinkle reduction with proper formulation one can envision that the engineered and if it is real protein can be used to treat surgical non-healing wound diabetic ulcer or pressure ulcers in out person these are tremendous medical burden to the our society in the battlefield the soldiers is constantly facing many dangerous situations ranging from exposure to blast the expose blast or inhalation of chemical toxic chemicals these can cause significant injury to one important organ in our body that is the lungs they're not alone we have shown that mg 53 can leave it acute lung injury in animal models now imagine if we can develop the protein to cheat acute lung injury to our soldiers in the battlefield so we have recently received support from the Department of Defense of the United States for this purpose so this project have two goals first we aim develops the protein as a first aid medicine that can be administered by the soldiers at a time they get injured to the lung or even you can apply the protein prior to the injury in the form of our saliva this is a medication that has been used to treat as an inhalation to treat asthma the second goal we want to do is that will attach this lyophilizer protein to an infusion bag so because of the proteins very stable and room temperature this enables our to store the protein for long-term storage as a medical reserve the mixture of the protein with the saline solution can be done when the soldiers being transported to the medical care unit where you can deliver through IV infusion to repair injury to the law so clearly the further drug development and commercialization goes beyond the academia mission of the other research therefore I formulated a University's been of biotechnology company for this purpose named tree medicine which is a member of the larger utcc of the Ohio State University we greatly appreciate the support from the leadership of the Wexner Medical Center and the University together who have engaged in dialogue with the fda to obtain their guidance we have also developed a partnership with multiple pharmaceutical companies for the code development purpose this work will not be impossible without the collaboration in the support from many leading scientists here on the campus of the Ohio State University so within the College of Medicine in the area of surgery trauma transplantation cancer heart lung and brain so we are also more importantly we also received support complimentary from many other colleges here on Ohio State University our research has been endorsed and supported by multiple grants from the National Institute of Health the department's American Heart Association so we have a lot more ahead of us to do and we greatly appreciate your continued support together we can translate mg3 as a Pixy dust into reality for the savings of many human lives I thank you for your time attention you business capstone translate Orthodox Judaism.